In a world devastated by an outbreak, Brian, his girlfriend Bobby, his brother Danny and their friend, Kate, are heading to a beach where the brothers spent their childhood vacations expecting it to be a sanctuary. When their car breaks down on the road in the desert, they negotiate with a man called Frank, who is also stranded but without gas. He is trying to get his daughter Jodie to the hospital (she is infected with a disease of some kind), they all decide to travel together. During the journey, massive moral dilemmas arise, as events head into a downward spiral.

Top Cat and the gang face a new police chief, who is not at all happy with officer Dibble's performance in trying to prevent Top Cat's scams. Strickland, the new police chief, will test Top Cat and his gang while proving to be the greatest foe Top Cat has ever encountered.